Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions
Human immunodeficiency virus (HIV) remains a persistent public health concern throughout
the world. Substance use disorders (SUDs) are a common comorbidity that can worsen …
the world. Substance use disorders (SUDs) are a common comorbidity that can worsen …
Virus-induced membrane fusion in neurodegenerative disorders
C Osorio, A Sfera, JJ Anton, KG Thomas… - Frontiers in Cellular …, 2022 - frontiersin.org
A growing body of epidemiological and research data has associated neurotropic viruses
with accelerated brain aging and increased risk of neurodegenerative disorders. Many …
with accelerated brain aging and increased risk of neurodegenerative disorders. Many …
Animal models for studies of HIV-1 brain reservoirs
The HIV-1 often evades a robust antiretroviral-mediated immune response, leading to
persistent infection within anatomically privileged sites including the CNS. Continuous low …
persistent infection within anatomically privileged sites including the CNS. Continuous low …
Genomic factors and therapeutic approaches in HIV-associated neurocognitive disorders: a comprehensive review
A Borrajo, D Pérez-Rodríguez… - International Journal of …, 2023 - mdpi.com
HIV-associated neurocognitive disorders (HANDs) still persist despite improved life
expectancy, reduced viral loads, and decreased infection severity. The number of patients …
expectancy, reduced viral loads, and decreased infection severity. The number of patients …
The role of pannexin-1 channels in HIV and NeuroHIV pathogenesis
CA Hernandez, E Eliseo - Cells, 2022 - mdpi.com
The human immunodeficiency virus-1 (HIV) enters the brain shortly after infection, leading to
long-term neurological complications in half of the HIV-infected population, even in the …
long-term neurological complications in half of the HIV-infected population, even in the …
The Impact of COVID-19 on People Living with HIV-1 and HIV-1-Associated Neurological Complications
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative
pathogen of the coronavirus disease 2019 (COVID-19) pandemic, a fatal respiratory illness …
pathogen of the coronavirus disease 2019 (COVID-19) pandemic, a fatal respiratory illness …
Crossroads of drug abuse and HIV infection: neurotoxicity and CNS reservoir
Drug abuse is a common comorbidity in people infected with HIV. HIV-infected individuals
who abuse drugs are a key population who frequently experience suboptimal outcomes …
who abuse drugs are a key population who frequently experience suboptimal outcomes …
Antiretroviral therapy restores the homeostatic state of microglia in SIV-infected rhesus macaques
Microglia and macrophages are essential for homeostatic maintenance and innate immune
response in the brain. They are the first line of defense against infections such as HIV/SIV in …
response in the brain. They are the first line of defense against infections such as HIV/SIV in …
[HTML][HTML] The Impact of HIV on Early Brain Aging—A Pathophysiological (Re) View
Background/Objectives: This review aims to provide a comprehensive understanding of how
HIV alters normal aging trajectories in the brain, presenting the HIV-related molecular …
HIV alters normal aging trajectories in the brain, presenting the HIV-related molecular …
EV Tetraspanins in Regenerative Medicine
J Li, S Yue - Extracellular Vesicle: Biology and Translational …, 2024 - Springer
Extracellular vesicles (EVs) are biological nano-sized vesicles secreted by all cell types and
can be found in different species. EVs show promise in diagnostics and therapeutics due to …
can be found in different species. EVs show promise in diagnostics and therapeutics due to …