P granules are RNA/protein condensates in the germline of Caenorhabditis elegans.
Genetic analyses have begun to identify the proteins that regulate P granule assembly in the …

Canonical RNAi, one of the so-called RNA-silencing mechanisms, is defined as sequence-
specific RNA degradation induced by long double-stranded RNA (dsRNA). RNAi occurs in …

Evidence from animal studies and human famines suggests that starvation may affect the
health of the progeny of famished individuals. However, it is not clear whether starvation …

Mobile genetic elements threaten genome integrity in all organisms. RDE-3 (also known as
MUT-2) is a ribonucleotidyltransferase that is required for transposon silencing and RNA …

A 'sibling'species of the model organism Caenorhabditis elegans has long been sought for
use in comparative analyses that would enable deep evolutionary interpretations of …

In C. elegans, small RNAs enable transmission of epigenetic responses across multiple
generations. While RNAi inheritance mechanisms that enable" memorization" of ancestral …

Abstract dsRNA-mediated gene silencing is heritable in Caenorhabditis elegans, termed
RNAi inheritance. Spracklin et al. describe the results of a forward genetic... Gene silencing …

RNA-mediated interference (RNAi) is a conserved mechanism that uses small RNAs
(sRNAs) to silence gene expression. In the Caenorhabditis elegans germline, transcripts …

Germ granules are biomolecular condensates present in most animal germ cells. One
function of germ granules is to help maintain germ cell totipotency by organizing mRNA …

Piwi-interacting RNAs (piRNAs) are RNA effectors with key roles in maintaining genome
integrity and promoting fertility in metazoans. In Caenorhabditis elegans loss of piRNAs …