Tumours can arise from thyroid follicular cells if they acquire driver mutations that
constitutively activate the MAPK signalling pathway. In addition, a limited set of additional …

MicroRNAs (miRNAs) play vital roles in the regulation of gene expression, a process known
as miRNA-induced gene silencing. The human genome codes for many miRNAs, and their …

There is an urgent unmet need for robust and reliable biomarkers for early diagnosis,
prognosis, and prediction of response to specific treatments of many aggressive and deadly …

MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of
genes in various biological processes such as cell differentiation, metabolism, and …

Gynecologic sarcomas are uncommon neoplasms, the majority occurring in the uterus. Due
to the diverse nature of these, the description of “new” morphological types and the rarity of …

Extensive studies have focused on the misregulation of individual miRNAs in cancer. More
recently, mutations in the miRNA biogenesis and processing machinery have been …

DICER1 gene encodes an RNaseIII endoribonuclease essential for the cleavage of pre-
microRNA to mature microRNA. Germline DICER1 mutation results in DICER syndrome, a …

Background The genomic and transcriptomic landscape of widely invasive follicular thyroid
carcinomas (wiFTCs) and Hürthle cell carcinoma (HCC) are poorly characterized, and …

Mutational inactivation of the DICER1 gene causes aberrant micro-RNA maturation, which in
turn may have consequences for the posttranscriptional regulation of gene expression …

Tumors of the central nervous system (CNS) comprise the second most common group of
neoplasms in childhood. The incidence of germline predisposition among children with …