Tuberculosis (TB) remains a serious threat to global public health, responsible for an
estimated 1.5 million mortalities in 2018. While there are available therapeutics for this …

We are witnessing the growing menace of both increasing cases of drug-sensitive and drug-
resistant Mycobacterium tuberculosis strains and the challenge to produce the first new …

Background Combating the spread of drug resistant tuberculosis is a global health priority.
Whole genome association studies are being applied to identify genetic determinants of …

Application of molecular dynamics simulation technique has become a conventional
computational methodology to calculate significant processes at the molecular level. This …

Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the
excessive deposition of amyloids in the brain. The pathological features mainly include the …

The resurgence of tuberculosis and emergence of multidrug resistant isolates has focused
attention on the need for an improved understanding of molecular aspects of the disease …

Arylamides have been identified as direct InhA inhibitors which overcome the drug-
resistance problem of isoniazid, the first-line drug for tuberculosis treatment. However …

Tuberculosis (TB) remains a primary global health concern, necessitating the discovery and
development of new anti-TB drugs, mainly to combat drug-resistant strains. In this context …

A chemical investigation reveals that the resistance to acylation of an anti-tuberculosis drug,
isoniazid is a consequent result of the inclusion or exclusion of cucurbit [n] urils (n= 6 or 7) …

The increasing resistance of Mycobacterium tuberculosis to the existing drugs has alarmed
the worldwide scientific community. In an attempt to overcome this problem computer-aided …