Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple
organ systems due to an inactivating variant in either TSC1 or TSC2, resulting in the …

Tuberous sclerosis complex (TSC) is a multisystem developmental disorder caused by
mutations in the TSC1 or TSC2 genes, whose protein products are negative regulators of …

Whether post-transcriptional regulation of gene expression controls differentiation of stem
cells for tissue renewal remains unknown. Quiescent stem cells exhibit a low level of protein …

Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or
TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 …

The mechanistic target of rapamycin (mTOR) is a kinase at the center of an evolutionarily
conserved signaling pathway that orchestrates cell growth and metabolism. mTOR responds …

Many RNA-binding proteins (RBPs), particularly those associated with RNA granules,
promote pathological protein aggregation in neurodegenerative diseases. Here, we …

A deletion or duplication in the 16p11. 2 region is associated with neurodevelopmental
disorders, including autism spectrum disorder and schizophrenia. In addition to clinical …

Reciprocal copy number variations (CNVs) of 16p11. 2 are associated with a wide spectrum
of neuropsychiatric and neurodevelopmental disorders. Here, we use human induced …

Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in TSC1 or
TSC2. Patients frequently have epilepsy, autism spectrum disorder, and/or intellectual …