Genetic landscape of common epilepsies: advancing towards precision in treatment
Epilepsy, a neurological disease characterized by recurrent seizures, is highly
heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types …
heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types …
From next-generation sequencing to targeted treatment of non-acquired epilepsies
Introduction: Within the last decade, next-generation sequencing (NGS) has resulted in
remarkable advances in the field of epilepsy genetics. NGS has become a routine part of the …
remarkable advances in the field of epilepsy genetics. NGS has become a routine part of the …
Insights into potential targets for therapeutic intervention in epilepsy
C Zavala-Tecuapetla, M Cuellar-Herrera… - International journal of …, 2020 - mdpi.com
Epilepsy is a chronic brain disease that affects approximately 65 million people worldwide.
However, despite the continuous development of antiepileptic drugs, over 30% patients with …
However, despite the continuous development of antiepileptic drugs, over 30% patients with …
Structural insights into galanin receptor signaling
W Jiang, S Zheng - Proceedings of the National Academy of …, 2022 - National Acad Sciences
Galanin is a biologically active neuropeptide, and functions through three distinct G protein–
coupled receptors (GPCRs), namely GALR1, GALR2, and GALR3. GALR signaling plays …
coupled receptors (GPCRs), namely GALR1, GALR2, and GALR3. GALR signaling plays …
The relevance of inter-and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy
It is becoming increasingly clear that the genetic background of mice and rats, even in
inbred strains, can have a profound influence on measures of seizure susceptibility and …
inbred strains, can have a profound influence on measures of seizure susceptibility and …
[HTML][HTML] Alterations in DNA 5-hydroxymethylation patterns in the hippocampus of an experimental model of chronic epilepsy
Temporal lobe epilepsy (TLE) is a type of focal epilepsy characterized by spontaneous
recurrent seizures originating from the hippocampus. The epigenetic reprogramming …
recurrent seizures originating from the hippocampus. The epigenetic reprogramming …
Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord
S Zhu, X Hu, S Bennett, O Charlesworth… - Frontiers in …, 2022 - frontiersin.org
Galanin is a neurohormone as well as a neurotransmitter and plays versatile physiological
roles for the neuroendocrine axis, such as regulating food intake, insulin level and …
roles for the neuroendocrine axis, such as regulating food intake, insulin level and …
The galaninergic system: A target for cancer treatment
ML Sánchez, R Coveñas - Cancers, 2022 - mdpi.com
Simple Summary Peptidergic systems play an important role in cancer progression. The
galaninergic system (the peptide galanin and its receptors: galanin 1, 2 and 3) is involved in …
galaninergic system (the peptide galanin and its receptors: galanin 1, 2 and 3) is involved in …
Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis
TC Berger, MD Vigeland, HS Hjorthaug, L Etholm… - PLoS …, 2019 - journals.plos.org
Background and aims Mesial Temporal Lobe Epilepsy is characterized by progressive
changes of both neurons and glia, also referred to as epileptogenesis. No curative treatment …
changes of both neurons and glia, also referred to as epileptogenesis. No curative treatment …
Recent advances and current status of gene therapy for epilepsy
AJ Cai, K Gao, F Zhang, YW Jiang - World Journal of Pediatrics, 2024 - Springer
Background Epilepsy is a common neurological disorder with complex pathogenic
mechanisms, and refractory epilepsy often lacks effective treatments. Gene therapy is a …
mechanisms, and refractory epilepsy often lacks effective treatments. Gene therapy is a …