How animals evolved from a single-celled ancestor, transitioning from a unicellular lifestyle
to a coordinated multicellular entity, remains a fascinating question. Key events in this …

The structure and function of the barrier layers restricting the free diffusion of substances
between the central nervous system (brain and spinal cord) and the systemic circulation is of …

Membrane-associated guanylate kinases (MAGUKs) are a family of scaffold proteins that are
highly enriched in synapses and are responsible for organizing the numerous protein …

Abstract Discs large homolog 5 (DLG5), a key member of the membrane-associated
guanylate kinase (MAGUKs) family, is a scaffold molecule for signal transduction complexes …

The evolution of animals (metazoans) from their unicellular ancestors required the
emergence of novel mechanisms for cell adhesion and cell–cell communication. One of the …

The first animals arose more than six hundred million years ago, yet they left little impression
in the fossil record. Nonetheless, the cell biology and genome composition of the first …

MAGUKs are proteins that act as key scaffolds in surface complexes containing receptors,
adhesion proteins, and various signaling molecules. These complexes evolved prior to the …

How animals (metazoans) originated from their single-celled ancestors remains a major
question in biology. As transcriptional regulation is crucial to animal development …

SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of
protein complexes through physical interactions with a pool of proline-rich/noncanonical …

Many of the eukaryotic phylogenomic analyses published to date were based on alignments
of hundreds to thousands of genes. Frequently, in such analyses, the most realistic …