Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high
medical and socioeconomic burden. There is a growing interest in the biological …

Mental health disorders, particularly depression and anxiety, affect a significant number of
the global population. Several pathophysiological pathways for these disorders have been …

Studies reporting blood levels of the omega-3 polyunsaturated fatty acids, eicosapentaenoic
acid (EPA) and docosahexaenoic acid (DHA), were systematically identified in order to …

Background We now know that depression is associated with a chronic, low-grade
inflammatory response and activation of cell-mediated immunity, as well as activation of the …

Object Studies have suggested that depression was accompanied by oxidative stress
dysregulation, including abnormal total antioxidant capacity (TAC), antioxidants, free …

Neurodegenerative disorders are chronic and life-threatening conditions negatively affecting
the quality of patients' lives. They often have a genetic background, but oxidative stress and …

This paper reviews that cell-mediated-immune (CMI) activation and inflammation contribute
to depressive symptoms, including anhedonia; anxiety-like behaviors; fatigue and somatic …

This paper reviews the body of evidence that major depression is accompanied by a
decreased antioxidant status and by induction of oxidative and nitrosative (IO&NS) …

The changing of omega‐6/omega‐3 polyunsaturated fatty acids (PUFA) in the food supply of
Western societies occurred over the last 150 years is thought to promote the pathogenesis of …

Many studies support a crucial role for oxidative & nitrosative stress (O&NS) in the
pathophysiology of unipolar and bipolar depression. These disorders are characterized inter …