Fluid dynamics inside the brain barrier: current concept of interstitial flow, glymphatic flow, and cerebrospinal fluid circulation in the brain

T Nakada, IL Kwee - The Neuroscientist, 2019 - journals.sagepub.com
The discovery of the water specific channel, aquaporin, and abundant expression of its
isoform, aquaporin-4 (AQP-4), on astrocyte endfeet brought about significant advancements …

Fluid metabolic pathways after subarachnoid hemorrhage

J Zhou, P Guo, Z Guo, X Sun, Y Chen… - Journal of …, 2022 - Wiley Online Library
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular disease
with high mortality and morbidity. In recent years, a large number of studies have focused on …

[HTML][HTML] Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood–brain barrier:[: 17: O] H: 2: O JJVCPE MRI study

VJ Huber, H Igarashi, S Ueki, IL Kwee, T Nakada - Neuroreport, 2018 - journals.lww.com
The blood–brain barrier (BBB), which imposes significant water permeability restriction,
effectively isolates the brain from the systemic circulation. Seemingly paradoxical, the …

Brain glymphatic/lymphatic imaging by MRI and PET

DS Lee, M Suh, A Sarker, Y Choi - Nuclear Medicine and Molecular …, 2020 - Springer
Since glymphatic was proposed and meningeal lymphatic was discovered, MRI and even
PET were introduced to investigate brain parenchymal interstitial fluid (ISF), cerebrospinal …

[HTML][HTML] Erythropoietin-mediated activation of aquaporin-4 channel for the treatment of experimental hydrocephalus

M Rizwan Siddiqui, F Attar, V Mohanty, KS Kim… - Child's Nervous …, 2018 - Springer
Objective In this study, we investigate a neuroprotective agent, erythropoietin (EPO), in
animal hydrocephalus model and its potential reversal effects on hydrocephalus by altering …

[HTML][HTML] Application of 7 tesla magnetic resonance imaging for pediatric neurological disorders: early clinical experience

K Yamada, J Yoshimura, M Watanabe… - Journal of Clinical …, 2021 - ncbi.nlm.nih.gov
Ultra-high field magnetic resonance imaging (MRI) has been introduced for use in pediatric
developmental neurology. While higher magnetic fields have certain advantages, optimized …

Light and the Brain: A Clinical Case Depicting the Effects of Light on Brainwaves and Possible Presence of Plasma-like Brain Energy

Z Idris, Z Zakaria, AS Yee, DN Fitzrol, MI Ismail… - Brain Sciences, 2024 - mdpi.com
Light is an electromagnetic radiation that has visible and invisible wavelength spectrums.
Visible light can only be detected by the eyes through the optic pathways. With the presence …

[HTML][HTML] Reduced pituitary volume with relative T1 shortening correlates with behavior in Prader-Willi syndrome

K Yamada, M Watanabe, K Suzuki - Biomarkers in Neuropsychiatry, 2021 - Elsevier
Prader-Willi syndrome is a complex endocrinological and developmental disorder
characterized by hyperphagic, autistic, and obsessive behaviors, which have been …

Hydrocephalus shunt therapy: current titanium shunt valve implants obstructed by internal tissue proliferations identified as extracellular matrix membranes

HC Ludwig, M Reitemeyer, HC Bock, M Sigler - Child's Nervous System, 2020 - Springer
Purpose Shunt valves, required for treatment of hydrocephalus, demand for high
performance rates and lifelong excellent function. To overcome problems with traditional …

The Brain in Prader-Willi Syndrome

K Yamada - Eating Disorders, 2023 - Springer
Abstract Prader-Willi syndrome (PWS), a congenital genetic disorder, has received attention
due to its features, including hyperphagic behavior with a unique genetic background. While …