In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …

The p53 family of proteins evolved from a common ancestor into three separate genes
encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each …

Simple Summary The well-known tumor suppressor protein p53 plays important roles in
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …

p53, first described four decades ago, is now established as a master regulator of cellular
stress response, the “guardian of the genome”. p53 contributes to biological robustness by …

Germline and somatic TP53 variants play a crucial role during tumorigenesis. However,
genetic variations that solely affect the alternatively spliced p53 isoforms, p53β and p53γ …

Metastatic melanoma is one of the most aggressive tumors, with frequent mutations affecting
components of the MAPK pathway, mainly protein kinase BRAF. Despite promising initial …

Abstract∆ 122p53 mice (a model of∆ 133p53 isoform) are tumour-prone, have extensive
inflammation and elevated serum IL-6. To investigate the role of IL-6 we crossed∆ 122p53 …

Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an
extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar …

Prostate cancer is the second most common cancer in men, for which there are no reliable
biomarkers or targeted therapies. Here we demonstrate that elevated levels of Δ133TP53β …

Simple Summary TP53 is one of the most important tumor suppressor genes, which has
been found to be mutated in more than half of human cancers and is considered the …