Activatable fluorescent probes for in situ imaging of enzymes
As the main biomarkers of most diseases, enzymes play fundamental but extremely critical
roles in biosystems. High-resolution studies of enzymes using activatable in situ …
roles in biosystems. High-resolution studies of enzymes using activatable in situ …
Peptide-based supramolecular systems chemistry
Peptide-based supramolecular systems chemistry seeks to mimic the ability of life forms to
use conserved sets of building blocks and chemical reactions to achieve a bewildering array …
use conserved sets of building blocks and chemical reactions to achieve a bewildering array …
Enzymatic noncovalent synthesis
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications
Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …
including environmental sensitivity, high reactivity toward amines and biothiols (including …
Self-assembling prodrugs
AG Cheetham, RW Chakroun, W Ma… - Chemical Society Reviews, 2017 - pubs.rsc.org
Covalent modification of therapeutic compounds is a clinically proven strategy to devise
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …
A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly
SY Qin, JQ Feng, YJ Cheng, WL Liu, AQ Zhang… - Coordination Chemistry …, 2024 - Elsevier
In the last few decades, we have witnessed the great advances of molecular self-assembly
in biomedical applications. Among the building blocks for molecular self-assembly, peptide …
in biomedical applications. Among the building blocks for molecular self-assembly, peptide …
Integrating enzymatic self-assembly and mitochondria targeting for selectively killing cancer cells without acquired drug resistance
Targeting organelles by modulating the redox potential of mitochondria is a promising
approach to kill cancer cells that minimizes acquired drug resistance. However, it lacks …
approach to kill cancer cells that minimizes acquired drug resistance. However, it lacks …
Self-assembling peptides and their application in the treatment of diseases
S Lee, THT Trinh, M Yoo, J Shin, H Lee, J Kim… - International journal of …, 2019 - mdpi.com
Self-assembling peptides are biomedical materials with unique structures that are formed in
response to various environmental conditions. Governed by their physicochemical …
response to various environmental conditions. Governed by their physicochemical …
Tandem molecular self‐assembly in liver cancer cells
We herein describe the tandem molecular self‐assembly of a peptide derivative (1) that is
controlled by a combination of enzymatic and chemical reactions. In phosphate‐buffered …
controlled by a combination of enzymatic and chemical reactions. In phosphate‐buffered …
Enzymatic assemblies disrupt the membrane and target endoplasmic reticulum for selective cancer cell death
The endoplasmic reticulum (ER) is responsible for the synthesis and folding of a large
number of proteins, as well as intracellular calcium regulation, lipid synthesis, and lipid …
number of proteins, as well as intracellular calcium regulation, lipid synthesis, and lipid …