Concise review: a comprehensive analysis of reported adverse events in patients receiving unproven stem cell-based interventions

G Bauer, M Elsallab… - Stem cells translational …, 2018 - academic.oup.com
The promise of stem cell (SC) therapies to restore functions of damaged tissues and organs
brings enormous hope to patients, their families, loved ones, and caregivers. However, limits …

Cell-based therapeutic strategies for multiple sclerosis

NJ Scolding, M Pasquini, SC Reingold, JA Cohen - Brain, 2017 - academic.oup.com
The availability of multiple disease-modifying medications with regulatory approval to treat
multiple sclerosis illustrates the substantial progress made in therapy of the disease …

[HTML][HTML] Clarifying stem-cell therapy's benefits and risks

PW Marks, CM Witten, RM Califf - New England Journal of …, 2017 - Mass Medical Soc
Clarifying Stem-Cell Therapy’s Benefits and Risks | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Safety of autologous human schwann cell transplantation in subacute thoracic spinal cord injury

KD Anderson, JD Guest, WD Dietrich… - Journal of …, 2017 - liebertpub.com
The rationale for implantation of autologous human Schwann cells (SCs) in persons with
subacute spinal cord injury (SCI) is based on evidence that transplanted SCs are …

[HTML][HTML] Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions

BL Edlow, LRD Sanz, L Polizzotto, N Pouratian… - Neurocritical care, 2021 - Springer
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Balancing safety and innovation for cell-based regenerative medicine

P Marks, S Gottlieb - New England Journal of Medicine, 2018 - Mass Medical Soc
Balancing Safety and Innovation for Cell-Based Regenerative Medicine | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

[HTML][HTML] Tumorigenicity assessment of cell therapy products: The need for global consensus and points to consider

Y Sato, H Bando, M Di Piazza, G Gowing, C Herberts… - Cytotherapy, 2019 - Elsevier
Pluripotent stem cells offer the potential for an unlimited source for cell therapy products.
However, there is concern regarding the tumorigenicity of these products in humans, mainly …

[HTML][HTML] Ethical and regulatory issues of stem cell-derived 3-dimensional organoid and tissue therapy for personalised regenerative medicine

AR Harris, MJ Walker, F Gilbert - BMC medicine, 2022 - Springer
Background Regenerative medicine has the potential to treat genetic disorders and replace
damaged or missing tissue. The use of donor or animal tissue raises many well-known …

A mechanistic roadmap for the clinical application of cardiac cell therapies

E Marbán - Nature biomedical engineering, 2018 - nature.com
The development of cells for regenerative therapy has encountered many pitfalls on its path
to clinical translation. In cardiology, clinical studies of heart-targeted cell therapies began …

Results from phase I clinical trial with intraspinal injection of neural stem cells in amyotrophic lateral sclerosis: a long-term outcome

L Mazzini, M Gelati, DC Profico, G Sorarù… - Stem cells …, 2019 - academic.oup.com
The main objective of this phase I trial was to assess the feasibility and safety of
microtransplanting human neural stem cell (hNSC) lines into the spinal cord of patients with …