Precision medicine in human heart modeling: perspectives, challenges, and opportunities
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …
pathological conditions, four-chamber heart models have only been addressed recently; …
A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …
Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations
Since myocardial fibers drive the electric signal propagation throughout the myocardium,
accurately modeling their arrangement is essential for simulating heart electrophysiology …
accurately modeling their arrangement is essential for simulating heart electrophysiology …
[HTML][HTML] Electro-mechanical whole-heart digital twins: a fully coupled multi-physics approach
T Gerach, S Schuler, J Fröhlich, L Lindner… - Mathematics, 2021 - mdpi.com
Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …
medicine and support clinical decision making by providing a powerful tool to understand …
Patient-specific inverse modeling of in vivo cardiovascular mechanics with medical image-derived kinematics as input data: concepts, methods, and applications
JH Bracamonte, SK Saunders, JS Wilson, UT Truong… - Applied Sciences, 2022 - mdpi.com
Inverse modeling approaches in cardiovascular medicine are a collection of methodologies
that can provide non-invasive patient-specific estimations of tissue properties, mechanical …
that can provide non-invasive patient-specific estimations of tissue properties, mechanical …
Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators
Cardiac pump function arises from a series of highly orchestrated events across multiple
scales. Computational electromechanics can encode these events in physics-constrained …
scales. Computational electromechanics can encode these events in physics-constrained …
[HTML][HTML] Personalising left-ventricular biophysical models of the heart using parametric physics-informed neural networks
We present a parametric physics-informed neural network for the simulation of personalised
left-ventricular biomechanics. The neural network is constrained to the biophysical problem …
left-ventricular biomechanics. The neural network is constrained to the biophysical problem …
[HTML][HTML] 3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …
[HTML][HTML] Machine learning of multiscale active force generation models for the efficient simulation of cardiac electromechanics
High fidelity (HF) mathematical models describing the generation of active force in the
cardiac muscle tissue typically feature a large number of state variables to capture the …
cardiac muscle tissue typically feature a large number of state variables to capture the …