Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …

Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma
membrane rupture of cells in a specific section of a nephron, referred to as acute tubular …

Background Post‐intensive care syndrome (PICS) encompasses physical, cognition, and
mental impairments persisting after intensive care unit (ICU) discharge. Ultimately it …

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an
important pathway in human disease. The necroptosis pathway is induced by a variety of …

Acute kidney injury (AKI) has been widely recognized as an important risk factor for the
occurrence and development of chronic kidney disease (CKD). Even milder AKI has adverse …

Background Necroptosis is emerging as a new target for cancer immunotherapy as it is now
recognized as a form of cell death that increases tumor immunogenicity, which would be …

Renal tubular cell (RTC) death and inflammation contribute to the progression of obstructive
nephropathy, but its underlying mechanisms have not been fully elucidated. Here, we …

Renal fibrosis is a common consequence of various progressive nephropathies, including
obstructive nephropathy, and ultimately leads to kidney failure. Infiltration of inflammatory …

Mitochondria are well known as the centre of energy metabolism in eukaryotic cells.
However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative …