The arealization of the mammalian cortex is believed to be controlled by a combination of
intrinsic factors that are expressed in the cortex, and external signals, some of which are …

Neuronal morphological differentiation is regulated by numerous polypeptide growth factors
(neurotrophic factors). Recently, significant progress has been achieved in clarifying the …

Advances in cellular reprogramming and stem cell differentiation now enable ex vivo studies
of human neuronal differentiation. However, it remains challenging to elucidate the …

The past two decades have seen an explosion in our understanding of the origin and
development of the midbrain dopamine system. Much of this work has been focused on the …

The Slit genes encode secreted ligands that regulate axon branching, commissural axon
pathfinding and neuronal migration. The principal identified receptor for Slit is Robo …

Abstract The Netrin, Slit, Semaphorin, and Ephrin families of secreted proteins were
originally characterized in the nervous system as guidance cues for axons; however, recent …

Recent studies of molecular guidance cues including the Slit family of secreted proteins
have provided new insights into the mechanisms of cell migration. Initially discovered in the …

The facial somatosensory map in the cortex is derived from facial representations that are
first established at the brainstem level and then serially'copied'at each stage of the …

Disruptions to developmental cell signaling pathways and transcriptional cascades have
been implicated in tumor initiation, maintenance and progression. Resurgence of aberrant …

Cortical interneurons in rodents are generated in the ventral telencephalon and migrate
tangentially into the cortex. This process requires the coordinated action of many intrinsic …