Diagnosis and treatment of acute myocarditis: a review

E Ammirati, JJ Moslehi - Jama, 2023 - jamanetwork.com
Importance Acute myocarditis, defined as a sudden inflammatory injury to the myocardium,
affects approximately 4 to 14 people per 100 000 each year globally and is associated with …

Dilated cardiomyopathy: causes, mechanisms, and current and future treatment approaches

S Heymans, NK Lakdawala, C Tschöpe, K Klingel - The Lancet, 2023 - thelancet.com
Dilated cardiomyopathy is conventionally defined as the presence of left ventricular or
biventricular dilatation or systolic dysfunction in the absence of abnormal loading conditions …

2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic …

AR Lyon, T Lopez-Fernandez, LS Couch… - European Heart …, 2022 - academic.oup.com
ESC Guidelines e341 (1) the specific situation of the patient. In this respect, it is specified
that, unless otherwise provided for by national regulations, offlabel use of medication should …

Abatacept/ruxolitinib and screening for concomitant respiratory muscle failure to mitigate fatality of immune-checkpoint inhibitor myocarditis

JE Salem, M Bretagne, B Abbar, S Leonard-Louis… - Cancer Discovery, 2023 - AACR
Abstract Immune-checkpoint-inhibitor (ICI)–associated myotoxicity involves the heart
(myocarditis) and skeletal muscles (myositis), which frequently occur concurrently and are …

Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer

A Karlstaedt, J Moslehi, RA de Boer - Nature Reviews Cardiology, 2022 - nature.com
Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …

Sex-specific cardiovascular risks of cancer and its therapies

NS Wilcox, SJ Rotz, MK Mullen, EJ Song… - Circulation …, 2022 - Am Heart Assoc
In both cardiovascular disease and cancer, there are established sex-based differences in
prevalence and outcomes. Males and females may also differ in terms of risk of cardiotoxicity …

Cardiomuscular biomarkers in the diagnosis and prognostication of immune checkpoint inhibitor myocarditis

LH Lehmann, MB Heckmann, G Bailly, D Finke… - Circulation, 2023 - Am Heart Assoc
BACKGROUND: Immune checkpoint inhibitors (ICIs) are approved for multiple cancers but
can result in ICI-associated myocarditis, an infrequent but life-threatening condition …

Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis

T Won, HM Kalinoski, MK Wood, DM Hughes… - Cell reports, 2022 - cell.com
Immune checkpoint inhibitors (ICIs) are an effective therapy for various cancers; however,
they can induce immune-related adverse events (irAEs) as a side effect. Myocarditis is an …

Immune-checkpoint inhibitor-mediated myocarditis: CTLA4, PD1 and LAG3 in the heart

AZ Munir, A Gutierrez, J Qin, AH Lichtman… - Nature Reviews …, 2024 - nature.com
Immune-checkpoint inhibitors (ICIs) have revolutionized oncology, with nearly 50% of all
patients with cancer eligible for treatment with ICIs. However, patients on ICI therapy are at …

Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis

Y Zhang, C Sun, Y Li, J Qin, K Amancherla… - Science translational …, 2022 - science.org
Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer
treatment but are associated with myocarditis. Here, we report that tumor-bearing mice …