The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …

Autosomal recessive osteopetrosis (ARO) is a severe inherited bone disease characterized
by defective osteoclast resorption or differentiation. Clinical manifestations include dense …

One of the major challenges for discovering protein-protein interaction inhibitors is
identifying selective and druggable binding sites at the protein surface. Here, we report an …

Osteopetrosis is a condition characterized by increased bone mass due to defects in
osteoclast function or formation. In the last decades, the molecular dissection of …

Extracellular vesicles (EVs) are complex phospholipidic structures actively released by cells.
EVs are recognized as powerful means of intercellular communication since they contain …

Apoptotic bodies (ABs) traditionally considered as garbage bags that enclose residual
components of dead cells are gaining increasing attentions due to their potential roles in …

Osteopetroses are a heterogeneous group of rare genetic bone diseases sharing the
common hallmarks of reduced osteoclast activity, increased bone mass and high bone …

Several studies have shown the importance of Extracellular Vesicles (EVs) in the
intercellular communication between tumour and resident cells. Through EVs, tumour cells …

The remarkable stoichiometric flexibility of hydroxyapatite (HAp) enables the formation of a
variety of charged structural sites at the material's surface which facilitates bone remodeling …

Alkaline phosphatase (ALP) is a family of enzymes involved in the regulation of important
biological processes such as cell differentiation and bone mineralization. Monitoring the …