Reprogramming the genetic code

D de la Torre, JW Chin - Nature Reviews Genetics, 2021 - nature.com
The encoded biosynthesis of proteins provides the ultimate paradigm for high-fidelity
synthesis of long polymers of defined sequence and composition, but it is limited to …

[HTML][HTML] Synthetic chromosomes, genomes, viruses, and cells

JC Venter, JI Glass, CA Hutchison, S Vashee - Cell, 2022 - cell.com
Synthetic genomics is the construction of viruses, bacteria, and eukaryotic cells with
synthetic genomes. It involves two basic processes: synthesis of complete genomes or …

[HTML][HTML] Overlapping genes in natural and engineered genomes

BW Wright, MP Molloy, PR Jaschke - Nature Reviews Genetics, 2022 - nature.com
Modern genome-scale methods that identify new genes, such as proteogenomics and
ribosome profiling, have revealed, to the surprise of many, that overlap in genes, open …

SEVA 3.0: an update of the Standard European Vector Architecture for enabling portability of genetic constructs among diverse bacterial hosts

E Martínez-García, A Goni-Moreno… - Nucleic acids …, 2020 - academic.oup.com
Abstract The Standard European Vector Architecture 3.0 database (SEVA-DB 3.0,
http://seva. cnb. csic. es) is the update of the platform launched in 2013 both as a web-based …

[HTML][HTML] Growing a circular economy with fungal biotechnology: a white paper

V Meyer, EY Basenko, JP Benz, GH Braus… - Fungal biology and …, 2020 - Springer
Fungi have the ability to transform organic materials into a rich and diverse set of useful
products and provide distinct opportunities for tackling the urgent challenges before all …

[HTML][HTML] Enabling technology and core theory of synthetic biology

XE Zhang, C Liu, J Dai, Y Yuan, C Gao, Y Feng… - Science China Life …, 2023 - Springer
Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …

[HTML][HTML] Trimming the genomic fat: minimising and re-functionalising genomes using synthetic biology

X Xu, F Meier, BA Blount, IS Pretorius, T Ellis… - Nature …, 2023 - nature.com
Naturally evolved organisms typically have large genomes that enable their survival and
growth under various conditions. However, the complexity of genomes often precludes our …

Current trends in biopharmaceuticals production in Escherichia coli

L McElwain, K Phair, C Kealey, D Brady - Biotechnology letters, 2022 - Springer
Since the manufacture of the first biotech product for a fledgling biopharmaceutical industry
in 1982, Escherichia coli, has played an important role in the industrial production of …

[HTML][HTML] Context-dependent neocentromere activity in synthetic yeast chromosome VIII

S Lauer, J Luo, L Lazar-Stefanita, W Zhang… - Cell Genomics, 2023 - cell.com
Pioneering advances in genome engineering, and specifically in genome writing, have
revolutionized the field of synthetic biology, propelling us toward the creation of synthetic …

Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in Streptomyces genomes

N Lee, S Hwang, W Kim, Y Lee, JH Kim, S Cho… - Natural Product …, 2021 - pubs.rsc.org
Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …