Globally, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD)
epidemics is increasing rapidly and has huge financial and emotional costs. The purpose of …

Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Background The brain was once thought of as an insulin-insensitive organ. We now know
that the insulin receptor is present throughout the brain and serves important functions in …

Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

In the last two decades, numerous in vitro studies demonstrated that insulin receptors and
theirs downstream pathways are widely distributed throughout the brain. This evidence has …

The latest studies have indicated a strong relationship between systemic insulin resistance
(IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment …

Macronutrients–carbohydrates, fats, and proteins–supply the nutrients required for optimal
functioning. Inadequate intake compromises both physical and brain health. We synthesized …

Poor diet and obesity are associated with cognitive impairment throughout adulthood, and
increased dementia risk in aging. Here we review the current literature interrogating the …

Obesity has been associated with oxidative stress. Obese patients are at increased risk for
diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative …

Type 2 diabetes mellitus (T2DM) the most prevalent metabolic disease that has evolved into
a major public health issue. Concerning about its secondary complications, a growing body …