The importance of antimicrobial resistance in medical mycology

NAR Gow, C Johnson, J Berman, AT Coste… - Nature …, 2022 - nature.com
Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global
health care priority. Some analyses, including the O'Neill report, have predicted that deaths …

Candida auris Genetics and Emergence

A Chowdhary, K Jain, N Chauhan - Annual Review of …, 2023 - annualreviews.org
Candida auris is a multidrug-resistant fungal pathogen that presents a serious threat to
global human health. Since the first reported case in 2009 in Japan, C. auris infections have …

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Y Lee, E Puumala, N Robbins, LE Cowen - Chemical reviews, 2020 - ACS Publications
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …

Candida auris: Epidemiology, biology, antifungal resistance, and virulence

H Du, J Bing, T Hu, CL Ennis, CJ Nobile… - PLoS …, 2020 - journals.plos.org
First described in 2009 in Japan, the emerging multidrug-resistant fungal pathogen Candida
auris is becoming a worldwide public health threat that has been attracting considerable …

Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium

A Arastehfar, T Gabaldón, R Garcia-Rubio, JD Jenks… - Antibiotics, 2020 - mdpi.com
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …

Candida auris: Epidemiology, Diagnosis, Pathogenesis, Antifungal Susceptibility, and Infection Control Measures to Combat the Spread of Infections in Healthcare …

S Ahmad, W Alfouzan - Microorganisms, 2021 - mdpi.com
Candida auris, a recently recognized, often multidrug-resistant yeast, has become a
significant fungal pathogen due to its ability to cause invasive infections and outbreaks in …

[HTML][HTML] The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris

JM Rybak, CA Cuomo, PD Rogers - Current opinion in microbiology, 2022 - Elsevier
Highlights•C. auris exhibits resistance to multiple antifungal agents and represents a public
health threat.•The molecular mechanisms of antifungal resistance observed in C. auris vary …

[HTML][HTML] Roles of Hsp90 in Candida albicans morphogenesis and virulence

N Robbins, LE Cowen - Current opinion in microbiology, 2023 - Elsevier
Highlights•Hsp90 is a molecular chaperone that modulates the function of many client
proteins.•Morphogenesis is an important Candida albicans virulence trait.•Hsp90 regulates …

The quiet and underappreciated rise of drug-resistant invasive fungal pathogens

A Arastehfar, C Lass-Flörl, R Garcia-Rubio… - Journal of Fungi, 2020 - mdpi.com
Human fungal pathogens are attributable to a significant economic burden and mortality
worldwide. Antifungal treatments, although limited in number, play a pivotal role in …

Genome-wide analysis of experimentally evolved Candida auris reveals multiple novel mechanisms of multidrug resistance

H Carolus, S Pierson, JF Muñoz, A Subotić, RB Cruz… - MBio, 2021 - Am Soc Microbiol
Candida auris is globally recognized as an opportunistic fungal pathogen of high concern,
due to its extensive multidrug resistance (MDR). Still, molecular mechanisms of MDR are …