In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms

S Cankat, MU Demael, L Swadling - Cellular & molecular immunology, 2024 - nature.com
Members of the coronaviridae family are endemic to human populations and have caused
several epidemics and pandemics in recent history. In this review, we will discuss the …

Non-invasive vaccines: challenges in formulation and vaccine adjuvants

S Han, P Lee, HJ Choi - Pharmaceutics, 2023 - mdpi.com
Given the limitations of conventional invasive vaccines, such as the requirement for a cold
chain system and trained personnel, needle-based injuries, and limited immunogenicity …

Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both

S Beitari, G Agbayani, M Hewitt, D Duque… - Scientific Reports, 2023 - nature.com
A critical feature of the VSV vector platform is the ability to pseudotype the virus with different
glycoproteins from other viruses, thus altering cellular tropism of the recombinant virus. The …

Immunogenicity of SARS-CoV-2 spike antigens derived from Beta & Delta variants of concern

B Akache, TM Renner, M Stuible, N Rohani… - npj Vaccines, 2022 - nature.com
Using our strongly immunogenic SmT1 SARS-CoV-2 spike antigen platform, we developed
antigens based on the Beta & Delta variants of concern (VOC). These antigens elicited …

A CHO stable pool production platform for rapid clinical development of trimeric SARS‐CoV‐2 spike subunit vaccine antigens

S Joubert, M Stuible, S Lord‐Dufour… - Biotechnology and …, 2023 - Wiley Online Library
Protein expression from stably transfected Chinese hamster ovary (CHO) clones is an
established but time‐consuming method for manufacturing therapeutic recombinant …

[HTML][HTML] Production, purification and immunogenicity of Gag virus-like particles carrying SARS-CoV-2 components

AB Gashti, G Agbayani, S Hrapovic, N Nassoury… - Vaccine, 2024 - Elsevier
The virus-like particle (VLP) platform is a robust inducer of humoral and cellular immune
responses; hence, it has been used in vaccine development for several infectious diseases …

Harnessing nasal immunity with IgA to prevent respiratory infections

J Joseph - Immuno, 2022 - mdpi.com
The nasal cavity is a primary checkpoint for the invasion of respiratory pathogens. Numerous
pathogens, including SARS-CoV-2, S. pneumoniae, S. aureus, etc., can adhere/colonize …

[HTML][HTML] Mucosal vaccine development for respiratory viral infections

Y Lin, Z Hu, YX Fu, H Peng - hLife, 2024 - Elsevier
Mucosal vaccines have risen to prominence in the corona virus disease 2019 (COVID-19)
pandemic due to their ability to elicit both local antibody and tissue-resident T cell …

[HTML][HTML] Protective immunity induced by an inhaled SARS-CoV-2 subunit vaccine

E Elder, CB Revanna, C Johansson, RPA Wallin… - Vaccine, 2023 - Elsevier
Targeting the site of infection is a promising strategy for improving vaccine effectivity. To
date, licensed COVID-19 vaccines have been administered intramuscularly despite the fact …

Immunological study of COVID-19 vaccine candidate based on recombinant spike trimer protein from different SARS-CoV-2 variants of concern

E Rudi, P Martin Aispuro, E Zurita… - Frontiers in …, 2022 - frontiersin.org
The emergency of new SARS-CoV-2 variants that feature increased immune escape marks
an urgent demand for better vaccines that will provide broader immunogenicity. Here, we …