Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Tumorigenesis is a complex process involving dynamic interactions between malignant cells
and their surrounding stroma, including both the cellular and acellular components. Within …

Cancer-associated fibroblasts constitute a vital subpopulation of the tumor stroma and are
present in more than 90% of epithelial carcinomas. The overexpression of the serine …

Cancer‐associated fibroblasts (CAFs) are important in tumor microenvironment (TME)
driven cancer progression. However, CAFs are heterogeneous and still largely …

Fibroblast activation protein-α (FAP) is a type II integral serine protease that is specifically
expressed by activated fibroblasts. Cancer-associated fibroblasts (CAFs) in the tumor stroma …

Cancer associated fibroblasts (CAF) and the extracellular matrix (ECM) produced by them
have been recognized as key players in cancer biology and emerged as important targets …

Abstract Background Squamous cell carcinoma (SqCC) is a subtype of non-small cell lung
cancer for which patient prognosis remains poor. The extracellular matrix (ECM) is critical in …

Activated fibroblasts are key players in the injury response, tumorigenesis, fibrosis, and
inflammation. Dichotomous outcomes in response to varied stroma-targeted therapies in …

Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune
checkpoint blockade has improved survival for many patients with NSCLC, but most fail to …

Radiotherapeutic resistance is a major obstacle for the effective treatment of colorectal
cancer (CRC). MicroRNAs (miRNAs) play a critical role in chemoresistance and …