There are concepts in science that need time to overcome initial disbelief before finally
arriving at the moment when they are embraced by the research community. One of these …

Cells release nanometer-scale, lipid bilayer-enclosed biomolecular packages (extracellular
vesicles; EVs) into their surrounding environment. EVs are hypothesized to be intercellular …

Tumors are not isolated entities, but complex systemic networks involving cell-cell
communication between transformed and non-transformed cells. The milieu created by …

Besides their function in limiting blood loss and promoting wound healing, experimental
evidence has highlighted platelets as active players in all steps of tumorigenesis including …

In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …

Cancer recurrence after surgical resection remains a significant challenge in cancer therapy.
Platelets, which accumulate in wound sites and interact with circulating tumour cells (CTCs) …

Extracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in
size, including exosomes, microvesicles, and apoptotic bodies. They are released under …

Reinvigoration of exhausted CD8+ T (Tex) cells by checkpoint immunotherapy depends on
the activation of precursors of exhausted T (Tpex) cells, but the local anatomical context of …

Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high
amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic …

Insufficient vessel growth associated with ischemia remains an unresolved issue in vascular
medicine. Mesenchymal stem cells (MSCs) have been shown to promote angiogenesis via a …