Mitogen-activated protein kinases in innate immunity
JSC Arthur, SC Ley - Nature Reviews Immunology, 2013 - nature.com
Following pathogen infection or tissue damage, the stimulation of pattern recognition
receptors on the cell surface and in the cytoplasm of innate immune cells activates members …
receptors on the cell surface and in the cytoplasm of innate immune cells activates members …
Regulation of toll-like receptor (TLR) signaling pathway by polyphenols in the treatment of age-linked neurodegenerative diseases: focus on TLR4 signaling
Neuronal dysfunction initiates several intracellular signaling cascades to release different
proinflammatory cytokines and chemokines, as well as various reactive oxygen species. In …
proinflammatory cytokines and chemokines, as well as various reactive oxygen species. In …
Oxidative stress: a suitable therapeutic target for optic nerve diseases?
F Buonfiglio, EW Böhm, N Pfeiffer, A Gericke - Antioxidants, 2023 - mdpi.com
Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …
Targeting oxidative stress for treatment of glaucoma and optic neuritis
A Kimura, K Namekata, X Guo, T Noro… - Oxidative Medicine …, 2017 - Wiley Online Library
Glaucoma is a neurodegenerative disease of the eye and it is one of the leading causes of
blindness. Glaucoma is characterized by progressive degeneration of retinal ganglion cells …
blindness. Glaucoma is characterized by progressive degeneration of retinal ganglion cells …
Small-molecule kinase inhibitors for the treatment of nononcologic diseases
Z Xie, X Yang, Y Duan, J Han… - Journal of medicinal …, 2021 - ACS Publications
Great successes have been achieved in developing small-molecule kinase inhibitors as
anticancer therapeutic agents. However, kinase deregulation plays essential roles not only …
anticancer therapeutic agents. However, kinase deregulation plays essential roles not only …
Cell death pathways: a novel therapeutic approach for neuroscientists
In the first part, the following mechanisms involved in different forms of cell death are
considered, with a view to identifying potential therapeutic targets: tumour necrosis factor …
considered, with a view to identifying potential therapeutic targets: tumour necrosis factor …
ASK1 inhibition: a therapeutic strategy with multi-system benefits
Abstract p38 mitogen-activated protein kinases (P38α and β) and c-Jun N-terminal kinases
(JNK1, 2, and 3) are key mediators of the cellular stress response. However, prolonged P38 …
(JNK1, 2, and 3) are key mediators of the cellular stress response. However, prolonged P38 …
Roles of p38α mitogen‐activated protein kinase in mouse models of inflammatory diseases and cancer
J Gupta, AR Nebreda - The FEBS journal, 2015 - Wiley Online Library
The p38α mitogen‐activated protein kinase pathway not only regulates the production of
inflammatory mediators, but also controls processes related to tissue homeostasis, such as …
inflammatory mediators, but also controls processes related to tissue homeostasis, such as …
Oxidative stress‐induced diseases via the ASK1 signaling pathway
M Soga, A Matsuzawa, H Ichijo - International journal of cell …, 2012 - Wiley Online Library
Apoptosis signal‐regulating kinase 1 (ASK1) is a mitogen‐activated protein kinase (MAPK)
kinase kinase that activates the downstream MAPKs, c‐Jun N‐terminal kinase (JNK) and …
kinase kinase that activates the downstream MAPKs, c‐Jun N‐terminal kinase (JNK) and …
Mdivi-1 modulates macrophage/microglial polarization in mice with EAE via the inhibition of the TLR2/4-GSK3β-NF-κB inflammatory signaling axis
X Liu, X Zhang, X Niu, P Zhang, Q Wang, X Xue… - Molecular …, 2022 - Springer
Macrophage/microglial modulation plays a critical role in the pathogenesis of multiple
sclerosis (MS), which is an inflammatory disorder of the central nervous system. Dynamin …
sclerosis (MS), which is an inflammatory disorder of the central nervous system. Dynamin …