Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria
from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX …

The poor outcome of primary malignant brain tumours is predominantly due to local invasion
and local recurrence and their prognosis is highly dependent on the degree of resection …

Glioblastoma multiforme continues to be a devastating disease despite modest
improvements in survival achieved at present, and there is an urgent need for innovative …

Lack of effective treatments for aggressive breast cancer is still a major global health
problem. We have previously reported that photodynamic therapy using methylene blue as …

Photodynamic techniques such as photodynamic diagnosis (PDD), fluorescence-guided
tumour resection (FGR) and photodynamic therapy (PDT) are currently undergoing intensive …

Background: 5-Aminolevulinic acid (5-ALA) has already been applied clinically as a
photosensitizer. In this study, sonodynamically induced selective antitumour effect of 5-ALA …

Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-
brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10-40 …

5-Aminolevulinic acid (5-ALA) is an amino acid derivative and a precursor of protoporphyrin
IX (PpIX). The photophysical feature of PpIX is clinically used in photodynamic diagnosis …

Photodynamic therapy (PDT) employs non-toxic dyes called photosensitizers (PSs), which
absorb visible light to give the excited singlet state, followed by the long-lived triplet state …

Photodynamic therapy (PDT) consists of a laser light exposure of tumor cells
photosensitized by general or local administration of a pharmacological agent. Nowadays …