Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides,
and load these peptides onto major histocompatibility complex (MHC) class I and II …

Recent years have seen so-called natural killer T (NKT) cells emerge as important
regulators of the immune response. The existence of NKT-cell subsets, and other types of T …

We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T
helper cell (Th17) clones and that all IL-17–producing cells are contained in the CD161+ …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

▪ Abstract Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …

CD1d-restricted natural killer (NK) T cells are known to potently secrete T helper (Th) 1 and
Th2 cytokines and to mediate cytolysis, but it is unclear how these contrasting functional …

Using a mouse model in which tumors show a growth-regression-recurrence pattern, we
investigated the mechanisms for down-regulation of cytotoxic T lymphocyte–mediated tumor …

Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid stem cell
origin that populate all lymphoid organs including the thymus, spleen, and lymph nodes, as …

The CD1 family of major histocompatibility complex (MHC)-like molecules specializes in
presenting lipid and glycolipid antigens to α/β T lymphocytes, but little is known about the …