microRNA‐based diagnostic and therapeutic applications in cancer medicine

LF Sempere, AS Azmi, A Moore - Wiley Interdisciplinary …, 2021 - Wiley Online Library
It has been almost two decades since the first link between microRNAs and cancer was
established. In the ensuing years, this abundant class of short noncoding regulatory RNAs …

[HTML][HTML] MicroRNA amplification and detection technologies: opportunities and challenges for point of care diagnostics

VP Dave, TA Ngo, AK Pernestig, D Tilevik, K Kant… - Laboratory …, 2019 - Elsevier
The volume of point of care (POC) testing continues to grow steadily due to the increased
availability of easy-to-use devices, thus making it possible to deliver less costly care closer …

[HTML][HTML] Cancer epigenetics: Moving forward

A Nebbioso, FP Tambaro, C Dell'Aversana… - PLoS genetics, 2018 - journals.plos.org
Defects in chromatin modifiers and remodelers have been described both for hematological
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …

[HTML][HTML] Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications

L Zhang, X Meng, X Zhu, D Yang, R Chen, Y Jiang… - Molecular cancer, 2019 - Springer
There is growing evidence that regions of the genome that cannot encode proteins play an
important role in diseases. These regions are usually transcribed into long non-coding …

Recent advances in microRNA detection

Y Cheng, L Dong, J Zhang, Y Zhao, Z Li - Analyst, 2018 - pubs.rsc.org
The development of simple, robust, and reliable microRNA (miRNA) detection methods is of
great significance in the studies of the biological function of miRNAs, molecular diagnostics …

miRNA dysregulation in breast cancer

L Mulrane, SF McGee, WM Gallagher, DP O'Connor - Cancer research, 2013 - AACR
Abstract miRNAs have emerged, in the last decade, as key players in the carcinogenic
process, with many candidates identified as playing important roles in many aspects of …

[HTML][HTML] Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant …

A Rodríguez-Martínez, D de Miguel-Pérez… - Breast Cancer …, 2019 - Springer
Background Breast cancer patients under neoadjuvant chemotherapy includes a
heterogeneous group of patients who eventually develop distal disease, not detectable by …

[HTML][HTML] Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes

S Kurozumi, Y Yamaguchi, M Kurosumi… - Journal of human …, 2017 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs that regulate the function of target genes
at the post-transcriptional phase. miRNAs are considered to have roles in the development …

[HTML][HTML] Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response

M Sahraei, B Chaube, Y Liu, J Sun… - The Journal of …, 2019 - Am Soc Clin Investig
microRNA-21 (miR-21) is the most commonly upregulated miRNA in solid tumors. This
cancer-associated microRNA (oncomiR) regulates various downstream effectors associated …

Detection methods for microRNAs in clinic practice

M de Planell-Saguer, MC Rodicio - Clinical biochemistry, 2013 - Elsevier
MicroRNAs (miRNA) are short non-coding RNA molecules that regulate gene expression.
miRNAs profiles are specific for cell lineages and tissues, and their changes reflect …