Unpacking extracellular vesicles: RNA cargo loading and function
Extracellular vesicles (EVs) are a heterogeneous group of membrane‐enclosed structures
produced by prokaryotic and eukaryotic cells. EVs carry a range of biological cargoes …
produced by prokaryotic and eukaryotic cells. EVs carry a range of biological cargoes …
A task-specific encoding algorithm for RNAs and RNA-associated interactions based on convolutional autoencoder
RNAs play essential roles in diverse physiological and pathological processes by interacting
with other molecules (RNA/protein/compound), and various computational methods are …
with other molecules (RNA/protein/compound), and various computational methods are …
Phospholipid membranes as chemically and functionally tunable materials
The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes.
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …
Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism
Lipid droplets (LDs) are cellular organelles critical for lipid homeostasis, with intramyocyte
LD accumulation implicated in metabolic disorder-associated heart diseases. Here we …
LD accumulation implicated in metabolic disorder-associated heart diseases. Here we …
Cyclophospholipids enable a protocellular life cycle
OD Toparlak, L Sebastianelli, V Egas Ortuno, M Karki… - ACS …, 2023 - ACS Publications
There is currently no plausible path for the emergence of a self-replicating protocell,
because prevalent formulations of model protocells are built with fatty acid vesicles that …
because prevalent formulations of model protocells are built with fatty acid vesicles that …
Robust and tunable performance of a cell-free biosensor encapsulated in lipid vesicles
Cell-free systems have enabled the development of genetically encoded biosensors to
detect a range of environmental and biological targets. Encapsulation of these systems in …
detect a range of environmental and biological targets. Encapsulation of these systems in …
Plant condensates: no longer membrane-less?
IH Hatzianestis, F Mountourakis, S Stavridou… - Trends in Plant …, 2023 - cell.com
Cellular condensation is a reinvigorated area of study in biology, with scientific discussions
focusing mainly on the forces that drive condensate formation, properties, and functions …
focusing mainly on the forces that drive condensate formation, properties, and functions …
Periodic temperature changes drive the proliferation of self-replicating RNAs in vesicle populations
Growth and division of biological cells are based on the complex orchestration of
spatiotemporally controlled reactions driven by highly evolved proteins. In contrast, it …
spatiotemporally controlled reactions driven by highly evolved proteins. In contrast, it …
On the influence of nucleic acid backbone modifications on lipid nanoparticle morphology
Nucleic acid therapeutics represent a major advance toward treating diseases at their root
cause. However, nucleic acids are prone to degradation by serum endonucleases …
cause. However, nucleic acids are prone to degradation by serum endonucleases …
Roles of G4-DNA and G4-RNA in class switch recombination and additional regulations in b-lymphocytes
O Dézé, B Laffleur, M Cogné - Molecules, 2023 - mdpi.com
Mature B cells notably diversify immunoglobulin (Ig) production through class switch
recombination (CSR), allowing the junction of distant “switch”(S) regions. CSR is initiated by …
recombination (CSR), allowing the junction of distant “switch”(S) regions. CSR is initiated by …