The neurochemical profile quantified by in vivo 1H NMR spectroscopy

JMN Duarte, H Lei, V Mlynárik, R Gruetter - Neuroimage, 2012 - Elsevier
Proton NMR spectroscopy is emerging from translational and preclinical neuroscience
research as an important tool for evidence based diagnosis and therapy monitoring. It …

Association between hyperglycemia and survival in patients with newly diagnosed glioblastoma

RL Derr, X Ye, MU Islas, S Desideri… - Journal of clinical …, 2009 - ascopubs.org
Purpose Hyperglycemia has been associated with poor outcomes in many disease states.
This retrospective study assessed the association between hyperglycemia and survival in …

[HTML][HTML] Glucose fluxes in glycolytic and oxidative pathways detected in vivo by deuterium magnetic resonance spectroscopy reflect proliferation in mouse …

RV Simões, RN Henriques, BM Cardoso… - NeuroImage: Clinical, 2022 - Elsevier
Objectives Glioblastoma multiforme (GBM), the most aggressive glial brain tumors, can
metabolize glucose through glycolysis and mitochondrial oxidation pathways. While specific …

The impact of hyperglycemia on survival in glioblastoma: a systematic review and meta-analysis

VM Lu, A Goyal, LS Vaughan, KL McDonald - Clinical Neurology and …, 2018 - Elsevier
In the management of glioblastoma (GBM), there is a considerable predisposition to
hyperglycemia due to significant integration of corticosteroid therapy to treat predictable …

Targeting protein kinase CK2: evaluating CX-4945 potential for GL261 glioblastoma therapy in immunocompetent mice

L Ferrer-Font, L Villamañan, N Arias-Ramos… - Pharmaceuticals, 2017 - mdpi.com
Glioblastoma (GBM) causes poor survival in patients even with aggressive treatment.
Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment but …

Anti-pd-1 immunotherapy in preclinical gl261 glioblastoma: Influence of therapeutic parameters and non-invasive response biomarker assessment with mrsi-based …

S Wu, P Calero-Pérez, C Arús, AP Candiota - International journal of …, 2020 - mdpi.com
Glioblastomas (GBs) are malignant brain tumours with poor prognosis even after aggressive
therapy. Programmed cell death-1 (PD-1) immune checkpoint blockade is a promising …

DCE@ urLAB: a dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data

JE Ortuño, MJ Ledesma-Carbayo, RV Simões… - BMC …, 2013 - Springer
Background DCE@ urLAB is a software application for analysis of dynamic contrast-
enhanced magnetic resonance imaging data (DCE-MRI). The tool incorporates a friendly …

In vivo 13C magnetic resonance spectroscopy of a human brain tumor after application of 13C-1-enriched glucose

JP Wijnen, M Van der Graaf, TWJ Scheenen… - Magnetic resonance …, 2010 - Elsevier
OBJECTIVES: As a unique tool to assess metabolic fluxes noninvasively, 13C magnetic
resonance spectroscopy (MRS) could help to characterize and understand malignancy in …

Tracking Therapy Response in Glioblastoma Using 1D Convolutional Neural Networks

S Ortega-Martorell, I Olier, O Hernandez… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma (GB) is a malignant brain tumour with no cure, even after the
best treatment. The evaluation of a therapy response is usually based on magnetic …

Anti‐tumour immune response in GL261 glioblastoma generated by Temozolomide Immune‐Enhancing Metronomic Schedule monitored with MRSI‐based …

S Wu, P Calero‐Pérez, L Villamañan… - NMR in …, 2020 - Wiley Online Library
Glioblastomas (GB) are brain tumours with poor prognosis even after aggressive therapy.
Improvements in both therapeutic and follow‐up strategies are urgently needed. In previous …