Glucokinase–maturity-onset diabetes of the young (GCK-MODY), also known as MODY2, is
caused by heterozygous inactivating mutations in the GCK gene. GCK gene mutations are …

Glucokinase is a key regulatory enzyme in the pancreatic beta‐cell. It plays a crucial role in
the regulation of insulin secretion and has been termed the glucose sensor in pancreatic …

Diabetes mellitus (DM) is a non-communicable, metabolic disorder that affects 416 million
individuals worldwide. Type 2 diabetes contributes to a vast 85–90% of the diabetes …

Background Maturity‐onset diabetes of the young (MODY) is a form of monogenic diabetes
with autosomal dominant inheritance. To date, mutations in 11 genes have been frequently …

Pruhova S, Dusatkova P, Sumnik Z, Kolouskova S, Pedersen O, Hansen T, Cinek O, Lebl J.
Glucokinase diabetes in 103 families from a country‐based study in the Czech Republic …

Aim: To perform molecular analysis of pediatric maturity onset diabetes of the young (MODY)
patients by next-generation sequencing, which enables simultaneous analysis of multiple …

Background Maturity-onset diabetes of the young (MODY) is a common form of monogenic
diabetes. Fourteen genes have been identified, each leading to cause a different type of …

Objective Inactivating heterozygous mutations in the GCK gene are a common cause of
MODY and result in mild fasting hyperglycaemia, which does not require treatment. We …

The prevalent RNA alternative splicing (AS) contributes to molecular diversity, which has
been demonstrated in cellular function regulation and disease pathogenesis. However, the …

The pituitary gland produces hormones that play important roles in both the development
and the homeostasis of the body. A deficiency of two or several of these pituitary hormones …