Linezolid administration to critically ill patients: intermittent or continuous infusion? A systematic literature search and review

LA Hui, C Bodolea, L Vlase, EI Hiriscau, A Popa - Antibiotics, 2022 - mdpi.com
A judicious antibiotic therapy is one of the challenges in the therapy of critically ill patients
with sepsis and septic shock. The pathophysiological changes in these patients significantly …

[HTML][HTML] Korean guidelines for use of antibiotics for intra-abdominal infections in adults

YK Yoon, C Moon, J Kim, ST Heo, MS Lee… - Infection & …, 2022 - ncbi.nlm.nih.gov
The guidelines are intended to provide practical information for the correct use of antibiotics
for intra-abdominal infections in Korea. With the aim of realizing evidence-based treatment …

A high performance liquid chromatography-tandem mass spectrometry assay for therapeutic drug monitoring of 10 drug compounds commonly used for antimicrobial …

SK Neef, AD Hinderer, W Arbash, M Kinzig, F Sörgel… - Clinica Chimica …, 2024 - Elsevier
Background and aims Intensive care antibiotic treatment faces challenges due to substantial
pharmacokinetic differences in critically ill patients. Individualized antibiotic dosing guided …

Population Pharmacokinetic Model for Unbound Concentrations of Daptomycin in Patients with MRSA Including Patients Undergoing Hemodialysis

S Takahashi, Y Tsuji, N Holford, C Ogami… - European Journal of …, 2023 - Springer
Abstract Background and Objective Unbound daptomycin concentrations are responsible for
pharmacologically beneficial and adverse effects, although most previous reports have been …

Continuous versus intermittent linezolid infusion for critically ill patients with hospital-acquired and ventilator-associated pneumonia: efficacy and safety challenges

AEA Warda, RM Sarhan, HS Al-Fishawy… - Pharmaceuticals, 2022 - mdpi.com
High variability of linezolid blood concentrations with partial subtherapeutic levels was
observed in critically ill patients who received a standard intravenous dose of linezolid …

Genomic Characterization and Phylogenetic Analysis of Linezolid-Resistant Enterococcus from the Nostrils of Healthy Hosts Identifies Zoonotic Transmission

IN Abdullahi, C Lozano, M Zarazaga… - Current …, 2024 - Springer
Linezolid resistance in Enterococcus spp. is increasingly considered critically important and
a public health threat which mandates the need to understand their genomic contents and …

Therapeutics for vancomycin-resistant enterococcal bloodstream infections

KA Cairns, AA Udy, TN Peel, IJ Abbott… - Clinical Microbiology …, 2023 - Am Soc Microbiol
Vancomycin-resistant enterococci (VRE) are common causes of bloodstream infections
(BSIs) with high morbidity and mortality rates. They are pathogens of global concern with a …

[HTML][HTML] Risk factors for mortality after linezolid treatment of vancomycin-resistant Enterococcus bloodstream infection

ST Huang, JL Yang, CY Lin, SH Huang… - International Journal of …, 2023 - Elsevier
Objectives We analyzed the risk factors affecting linezolid treatment outcome in vancomycin-
resistant Enterococcus (VRE) bloodstream infection (BSI). Methods We conducted a …

[PDF][PDF] Rational use of antibiotics: an area of concern

S Sarkar, V Srivastava, SS Samajhdar… - Journal of Young …, 2022 - jyoungpharm.org
Most of the IPD (Inpatient department) and OPD (Outpatient department) patients receive a
course of antibiotics either for treatment or prevention of infection or during discharge. The …

Genome insights of Enterococcus raffinosus CX012922, isolated from the feces of a Crohn's disease patient

H Zhao, Y Peng, X Cai, Y Zhou, Y Zhou, H Huang, L Xu… - Gut Pathogens, 2021 - Springer
Background Enterococcus raffinosus is one of the Enterococcus species that often cause
nosocomial infections. To date, only one E. raffinosus genome has been completely …