Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Reinforcement learning in depression: A review of computational research

C Chen, T Takahashi, S Nakagawa, T Inoue… - … & Biobehavioral Reviews, 2015 - Elsevier
Despite being considered primarily a mood disorder, major depressive disorder (MDD) is
characterized by cognitive and decision making deficits. Recent research has employed …

Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson's disease: clues to early diagnosis and effective …

Y Bang, J Lim, HJ Choi - Archives of pharmacal research, 2021 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
movement dysfunction due to selective degeneration of dopaminergic neurons in the …

Physical training prevents depressive symptoms and a decrease in brain-derived neurotrophic factor in Parkinson's disease

T Tuon, SS Valvassori, GC Dal Pont, CS Paganini… - Brain Research …, 2014 - Elsevier
Depression is a neuropsychiatric disorder that is commonly found in patients with
Parkinson's disease (PD). Many studies have suggested that physical exercise can have an …

Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson's disease is mediated by a reduction of inducible nitric oxide …

MA Mori, AM Delattre, B Carabelli, C Pudell… - Nutritional …, 2018 - Taylor & Francis
Objective: Parkinson's disease (PD) is characterized by deterioration of the nigrostriatal
system and associated with chronic neuroinflammation. Glial activation has been associated …

The hidden side of Parkinson's disease: Studying pain, anxiety and depression in animal models

F Faivre, A Joshi, E Bezard, M Barrot - Neuroscience & Biobehavioral …, 2019 - Elsevier
Parkinson's disease is a neurodegenerative disease leading to the loss of midbrain
dopamine neurons. It is well known and characterized by motor symptoms that are …

Dopamine receptor D3 deficiency results in chronic depression and anxiety

R Moraga-Amaro, H Gonzalez, R Pacheco… - Behavioural brain …, 2014 - Elsevier
Over the last decade accumulating evidence suggests that brain dopamine (DA) has a role
in depression, particularly given the high comorbidity of depression with Parkinson's …

What can rodent models tell us about apathy and associated neuropsychiatric symptoms in Parkinson's disease?

R Magnard, Y Vachez, C Carcenac, P Krack… - Translational …, 2016 - nature.com
In addition to classical motor symptoms, Parkinson's disease (PD) patients display
incapacitating neuropsychiatric manifestations, such as apathy, anhedonia, depression and …

[HTML][HTML] Mood disturbances in Parkinson's disease: From prodromal origins to application of animal models

S Hayley, F Vahid-Ansari, H Sun, PR Albert - Neurobiology of Disease, 2023 - Elsevier
Parkinson's disease (PD) is a complex illness with a constellation of environmental insults
and genetic vulnerabilities being implicated. Strikingly, many studies only focus on the …

Anxiety-like behavior induced by 6-OHDA animal model of Parkinson's disease may be related to a dysregulation of neurotransmitter systems in brain areas related to …

JCF Vieira, TB Bassani, RM Santiago, GO Guaita… - Behavioural brain …, 2019 - Elsevier
Anxiety in Parkinson's disease may represent a physiological reaction to the development of
other symptoms during disease progression. However, evidence suggests that the incidence …