Actomyosin contractility is a highly regulated process that affects many fundamental
biological processes in each and every cell in our body. In this Cell Science at a Glance …

Epithelial cells exfoliated in human urine can include cells anywhere from the urinary tract
and kidneys; however, podocytes and proximal tubular epithelial cells (PTECs) are by far the …

The architectural integrity of tissues requires complex interactions, both between cells and
between cells and the extracellular matrix. Fundamental to cell and tissue homeostasis are …

Background The discoidin domain receptor 1 (DDR1) is activated by collagens, upregulated
in injured and fibrotic kidneys, and contributes to fibrosis by regulating extracellular matrix …

Intronic variants of the MYH9 gene that encodes the nonmuscle myosin heavy chain IIA are
associated with diabetic nephropathy in European Americans and with sickle cell disease …

The binder of rho GTPases (BORG)/Cdc42 effector proteins (Cdc42EP) family is composed
of five Rho GTPase binding proteins whose functions and mechanism of actions are of …

Glomerular epithelial cells, podocytes, are insulin responsive and can develop insulin
resistance. Here, we demonstrate that the small GTPase septin 7 forms a complex with …

Currently, the major measures of preventing and controlling microbial infection are
vaccinations and drugs. However, the appearance of drug resistance microbial mounts is …

Several glomerular pathologies resulting from podocyte injury are linked to genetic variation
involving the MYH9 gene, which encodes the heavy chain of non‐muscle myosin‐IIA (NM …

Podocyte damage is one of the hallmarks of diabetic nephropathy leading to proteinuria and
kidney damage. The underlying mechanisms of podocyte injury are not well defined …