Due to the advantages of in situ, real-time, and non-destructive detection of target
molecules, fluorescent probes have become an indispensable tool in the fields of disease …

Carbohydrates are fundamental molecules involved in nearly all aspects of lives, such as
being involved in formating the genetic and energy materials, supporting the structure of …

Niemann–Pick disease type C (NP-C) is a rare inherited neurovisceral disease caused by
mutations in either the NPC1 (in 95% of cases) or the NPC2 gene (in around 5% of cases) …

A growing trend for nutraceutical and gluten-free cereal-based products highlights the need
for development of new products. Buckwheat is one of the potential candidates for such …

We recently showed that human skin fibroblasts internalize fluorescent analogues of the
glycosphingolipids lactosylceramide and globoside almost exclusively by a clathrin …

Increased understanding of the role of protein-and lipid-linked carbohydrates in a wide
range of biological processes has led to interest in drugs that target the enzymes involved in …

The search for carbohydrate mimetics-based glycosyltransferase inhibitors is a dynamic field
that emerged 10 years ago. This review presents a description of the different types of …

Niemann-Pick disease type C (NP-C) is a lysosomal storage disease in which impaired
intracellular lipid trafficking leads to excess storage of cholesterol and glycosphingolipids in …

The inherited metabolic disorders of glycosphingolipid (GSL) metabolism are a relatively
rare group of diseases that have diverse and often neurodegenerative phenotypes …

Miglustat has been shown to stabilize disease progression in children, juveniles and adults
with Niemann-Pick disease type C (NP-C), a rare genetic disorder characterized by …