Diabetic macroangiopathy, atherosclerosis secondary to diabetes mellitus (DM), causes
cerebro-cardiovascular diseases, which are major causes of death in patients with DM and …

The receptor for advanced glycation end-products (RAGE) is a multiligand pattern
recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and …

The receptor for advanced glycation end-product (RAGE) is the signal transduction receptor
which senses a variety of signalling molecules including advanced glycation end products …

ABSTRACT RAGE is a key molecule in the onset and sustainment of the inflammatory
response. New studies indicate that RAGE might represent a new link between the innate …

Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular
events, dementia, and death. Decreased compliance of the central vasculature alters arterial …

High-mobility group box 1 protein (HMGB1), which previously was thought to function only
as a nuclear factor that enhances transcription, was recently discovered to be a crucial …

The immune system has evolved to respond not only to pathogens, but also to signals
released from dying cells. Cell death through necrosis induces inflammation, whereas …

Amyloid-β peptide (Aβ) interacts with the vasculature to influence Aβ levels in the brain and
cerebral blood flow, providing a means of amplifying the Aβ-induced cellular stress …

Advanced glycation end products (AGEs), S100/calgranulins, HMGB1-proteins, amyloid-β
peptides, and the family of β-sheet fibrils have been shown to contribute to a number of …

Diabetes is well established as a chronic disease with a high health burden due to mortality
or morbidity from the final outcomes of vascular complications. An increased duration of …