The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Polymeric micelles are demonstrating high potential as nanomedicines capable of
controlling the distribution and function of loaded bioactive agents in the body, effectively …

Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles
that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid …

Many emerging therapies rely on the delivery of biological cargo into the cytosol.
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …

The targeted and efficiency-oriented delivery of (therapeutic) nucleic acids raises hope for
successful gene therapy, ie, for the local and individual treatment of acquired and inherited …

Intracellular delivery of biological agents such as peptides, proteins, and nucleic acids
generally rely on the endocytic pathway as the major uptake mechanism, resulting in their …

Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

In non-viral gene therapy, cationic polymers and lipids are frequently used to encapsulate
macromolecular therapeutics into nanoparticles. During their journey to deliver the cargo to …

Using nanoparticles to deliver drugs to cells has the potential to revolutionize the treatment
of many diseases, including HIV, cancer, and diabetes. One of the major challenges facing …

Polycations such as polyethylenimine (PEI) are used in many novel nonviral vector designs
and there are continuous efforts to increase our mechanistic understanding of their …