In this review, we summarize the multiple functions of NQO1, its established roles in redox
processes and potential roles in redox control that are currently emerging. NQO1 has …

Oxidative stress as a concept in redox biology and medicine has witnessed fulminant
development of the past 30-odd years. It is a global concept, defined as “an imbalance …

NQO1 is one of the two major quinone reductases in mammalian systems. It is highly
inducible and plays multiple roles in cellular adaptation to stress. A prevalent polymorphic …

Oxidative stress (OS), caused by the imbalance between the generation and detoxification of
reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging …

Bcl-2 inhibits most types of apoptotic cell death, implying a common mechanism of lethality.
Bcl-2 is localized to intracellular sites of oxygen free radical generation including …

This review deals with the permeability transition (PT) of isolated mitochondria, a field
spawned at the very beginning of mitochondrial research by the observation that the …

Cell survival requires multiple factors, including appropriate proportions of molecular oxygen
and various antioxidants. Although most oxidative insults can be overcome by the cell's …

Quinones are probably found in all respiring animal and plant cells. They are widely used as
anticancer, antibacterial or antimalarial drugs and as fungicides. Toxicity can arise as a …

Free radicals and other reactive oxygen species (ROS) are constantly formed in the human
body, often for useful metabolic purposes. Antioxidant defenses protect against them, but …

Quinones are ubiquitous in nature and constitute an important class of naturally occurring
compounds that are found in plants, fungi, and bacteria and that function primarily as …