Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and
systemic glucose metabolism. Postnatal ablation of insulin receptors (IRs) in glial fibrillary …

Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of
the body's energy status, since they act in an opposite manner to modulate appetite and …

Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic
feeding circuits. These non-neuronal cells are crucial in determining the functional …

Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior.
Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes …

Leptin is the most critical hormone in the homeostatic regulation of energy balance among
those so far discovered. Leptin primarily acts on the neurons of the mediobasal part of …

We found that leptin receptors were expressed in hypothalamic astrocytes and that their
conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …