The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Transfer RNA is an essential adapter molecule that is found across all three domains of life.
The primary role of transfer RNA resides in its critical involvement in the accurate translation …

Custom-designed gene chips (Affymetrix) were used to determine genetic relatedness and
gene expression profiles in Staphylococcus aureus isolates with increasing MICs of …

Objectives Ceftaroline, approved in Europe in 2012, has activity against methicillin-resistant
Staphylococcus aureus (MRSA), with MIC90 values of 1–2 mg/L depending on geographical …

The factor catalyzing the first step in the synthesis of the characteristic pentaglycine
interpeptide in Staphylococcus aureus peptidoglycan was found to be encoded by the …

Bacterial cells are surrounded by cell wall, whose main component is peptidoglycan (PG), a
macromolecule that withstands the internal turgor of the cell. PG composition can vary …

Peptidoglycan biosynthesis is one of the preferred targets for antibiotics, as peptidoglycan is
unique to eubacteria and inhibition of its production is generally bactericidal (Fig. 1) …

Staphylococcus aureus (S. aureus) is one of the critical clinical pathogens which can cause
multiple diseases ranging from skin infections to fatal sepsis. S. aureus is generally …

The WalKR two-component system is essential for viability of Staphylococcus aureus, a
major pathogen. We have shown that WalKR acts as the master controller of peptidoglycan …

Pathogen-specific antibiotics kill the offending species without inviting the patient's flora to
help develop a resistance mechanism. The current scarcity of pathogen-specific antibiotics …