Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

The X inactive-specific transcript (Xist) gene is the master regulator of X chromosome
inactivation in mammals. Xist produces a long noncoding (lnc) RNA that accumulates over …

Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest
cavity. To expand our understanding of MPM, we conducted a comprehensive integrated …

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional
dysregulation that results in a block in differentiation and increased malignant self-renewal …

A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …

Animal cloning can be achieved through somatic cell nuclear transfer (SCNT), although the
live birth rate is relatively low. Recent studies have identified H3K9me3 in donor cells and …

In each somatic cell of a female mammal one X chromosome is transcriptionally silenced via
X-chromosome inactivation (XCI), initiating early in development. Although XCI events are …

Systematic variation in the methylation of cytosines at CpG sites plays a critical role in early
development of humans and other mammals. Of particular interest are regions of differential …

In female eutherian mammals, dosage compensation of X-linked gene expression is
achieved during development through transcriptional silencing of one of the two X …

The regulation of higher-order chromatin structure is complex and dynamic, and a full
understanding of the suite of mechanisms governing this architecture is lacking. Here, we …