[HTML][HTML] Detection of ancient viruses and long-term viral evolution

L Nishimura, N Fujito, R Sugimoto, I Inoue - Viruses, 2022 - mdpi.com
The COVID-19 outbreak has reminded us of the importance of viral evolutionary studies as
regards comprehending complex viral evolution and preventing future pandemics. A unique …

Unmasking the tissue-resident eukaryotic DNA virome in humans

L Pyöriä, D Pratas, M Toppinen, K Hedman… - Nucleic Acids …, 2023 - academic.oup.com
Little is known on the landscape of viruses that reside within our cells, nor on the interplay
with the host imperative for their persistence. Yet, a lifetime of interactions conceivably have …

Efficient DNA sequence compression with neural networks

M Silva, D Pratas, AJ Pinho - GigaScience, 2020 - academic.oup.com
Background The increasing production of genomic data has led to an intensified need for
models that can cope efficiently with the lossless compression of DNA sequences. Important …

The landscape of persistent human DNA viruses in femoral bone

M Toppinen, D Pratas, E Väisänen… - Forensic Science …, 2020 - Elsevier
The imprints left by persistent DNA viruses in the tissues can testify to the changes driving
virus evolution as well as provide clues on the provenance of modern and ancient humans …

Reactivation of a transplant recipient's inherited human herpesvirus 6 and implications to the graft

L Hannolainen, L Pyöriä, D Pratas, J Lohi… - The Journal of …, 2024 - academic.oup.com
Background The implications of inherited chromosomally integrated human herpesvirus 6
(iciHHV-6) in solid organ transplantation remain uncertain. Although this trait has been …

Minirmd: accurate and fast duplicate removal tool for short reads via multiple minimizers

Y Liu, X Zhang, Q Zou, X Zeng - Bioinformatics, 2021 - academic.oup.com
Removing duplicate and near-duplicate reads, generated by high-throughput sequencing
technologies, is able to reduce computational resources in downstream applications. Here …

[PDF][PDF] Sousa

RCM PEREIRA - PA Fatores de mortalidade de micro e pequenas, 2018 - researchgate.net
The increasing availability of expressive quantities of human viral sequenced samples,
namely from clinical and forensic contexts, has led to the emergence of many optimized …

[HTML][HTML] The human bone marrow is host to the DNAs of several viruses

M Toppinen, A Sajantila, D Pratas… - Frontiers in cellular …, 2021 - frontiersin.org
The long-term impact of viruses residing in the human bone marrow (BM) remains
unexplored. However, chronic inflammatory processes driven by single or multiple viruses …

Methods for measuring the evolutionary stability of engineered genomes to improve their longevity

SL Nuismer, N C. Layman, AJ Redwood… - Synthetic …, 2021 - academic.oup.com
Diverse applications rely on engineering microbes to carry and express foreign transgenes.
This engineered baggage rarely benefits the microbe and is thus prone to rapid evolutionary …

[HTML][HTML] Rapid genotyping of targeted viral samples using Illumina short-read sequencing data

A Váradi, E Kaszab, G Kardos, E Prépost, K Szarka… - Plos one, 2022 - journals.plos.org
The most important information about microorganisms might be their accurate genome
sequence. Using current Next Generation Sequencing methods, sequencing data can be …