Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most highly utilized
classes of pharmaceutical agents in medicine. All NSAIDs act through inhibiting …

Objectives This review attempts to bring together information from a large number of recent
studies on the clinical uses, safety and pharmacological properties of ibuprofen. Ibuprofen is …

Background Each year, clinical upper gastrointestinal events occur in 2 to 4 percent of
patients who are taking nonselective nonsteroidal antiinflammatory drugs (NSAIDs). We …

Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual
pain, and headache. Although they are effective, their long-term use is limited by …

Atherosclerosis is a process with inflammatory features and selective cyclooxygenase 2
(COX-2) inhibitors may potentially have antiatherogenic effects by virtue of inhibiting …

Osteoarthritis is a painful and disabling disease that affects millions of patients. Its aetiology
is largely unknown, but is most likely multi-factorial. Osteoarthritis poses a dilemma: it often …

▪ Abstract Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is
the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX …

Background The cyclo-oxygenase 2 inhibitor rofecoxib was recently withdrawn because of
cardiovascular adverse effects. An increased risk of myocardial infarction had been …

Context Authorship in biomedical publication provides recognition and establishes
accountability and responsibility. Recent litigation related to rofecoxib provided a unique …

By inhibiting prostaglandin synthesis, non-steroidal anti-inflammatory drugs (NSAIDs) cause
mucosal damage, ulceration and ulcer complication throughout the gastrointestinal tract …