Clinical pharmacology of corticosteroids

DM Williams - Respiratory care, 2018 - rc.rcjournal.com
Corticosteroids have numerous applications in treating inflammation and diseases of
immune function based on their significant anti-inflammatory and immunosuppressive …

Inhaled corticosteroids: potency, dose equivalence and therapeutic index

PT Daley‐Yates - British journal of clinical pharmacology, 2015 - Wiley Online Library
Glucocorticosteroids are a group of structurally related molecules that includes natural
hormones and synthetic drugs with a wide range of anti‐inflammatory potencies. For …

[HTML][HTML] Inhaled corticosteroids

PJ Barnes - Pharmaceuticals, 2010 - mdpi.com
Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They suppress
inflammation mainly by switching off multiple activated inflammatory genes through …

Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma

H Derendorf, R Nave, A Drollmann… - European …, 2006 - Eur Respiratory Soc
The pharmacokinetic and pharmacodynamic effects of inhaled corticosteroids (ICS) have
shaped the efficacy and safety of these agents in the treatment of asthma. Important …

Inhaled corticosteroids: past lessons and future issues

DB Allen, L Bielory, H Derendorf, R Dluhy… - Journal of Allergy and …, 2003 - Elsevier
Inhaled corticosteroids play a pivotal role in the treatment of asthma. Inhalation permits
effective delivery of the corticosteroid in high concentration to target sites within the lung …

Adrenal suppression and Cushing's syndrome secondary to an interaction between ritonavir and fluticasone: a review of the literature

MM Foisy, EMK Yakiwchuk, I Chiu, AE Singh - HIV medicine, 2008 - Wiley Online Library
Objective The purpose of this article is to provide a systematic overview of the literature on
adrenal suppression and Cushing's syndrome secondary to an interaction between …

[HTML][HTML] Corticosteroids in COVID-19: pros and cons

A Bahsoun, Y Fakih, R Zareef, F Bitar, M Arabi - Frontiers in Medicine, 2023 - frontiersin.org
The wide and rapid spread of the COVID-19 pandemic has placed an unanticipated burden
on the global healthcare sector. This necessitated a swift response from the international …

The influence of lung deposition on clinical response

JN Pritchard - Journal of Aerosol Medicine, 2001 - liebertpub.com
Delivery of more drug to the lung may appear to be a desirable goal in the treatment of
asthma and chronic obstructive pulmonary disease, since only 10 to 15% of a drug dose …

Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma

R Buhl - Allergy, 2006 - Wiley Online Library
The widespread use of inhaled corticosteroids (ICS) for the treatment of persistent asthma,
although highly effective, may be associated with both systemic and local side effects …

Challenges in inhaled product development and opportunities for open innovation

B Forbes, B Asgharian, LA Dailey, D Ferguson… - Advanced drug delivery …, 2011 - Elsevier
Dosimetry, safety and the efficacy of drugs in the lungs are critical factors in the development
of inhaled medicines. This article considers the challenges in each of these areas with …