[PDF][PDF] Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
NJ Hogrebe, M Ishahak, JR Millman - Cell Stem Cell, 2023 - cell.com
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
[HTML][HTML] Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis
Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
Pancreatic islet transplantation in humans: recent progress and future directions
MR Rickels, RP Robertson - Endocrine reviews, 2019 - academic.oup.com
Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
E Kroon, LA Martinson, K Kadoya, AG Bang… - Nature …, 2008 - nature.com
Abstract Development of a cell therapy for diabetes would be greatly aided by a renewable
supply of human β-cells. Here we show that pancreatic endoderm derived from human …
supply of human β-cells. Here we show that pancreatic endoderm derived from human …
[HTML][HTML] International trial of the Edmonton protocol for islet transplantation
AMJ Shapiro, C Ricordi, BJ Hering… - … England Journal of …, 2006 - Mass Medical Soc
Background Islet transplantation offers the potential to improve glycemic control in a
subgroup of patients with type 1 diabetes mellitus who are disabled by refractory …
subgroup of patients with type 1 diabetes mellitus who are disabled by refractory …
Five stages of evolving beta-cell dysfunction during progression to diabetes
GC Weir, S Bonner-Weir - Diabetes, 2004 - Am Diabetes Assoc
This article proposes five stages in the progression of diabetes, each of which is
characterized by different changes in β-cell mass, phenotype, and function. Stage 1 is …
characterized by different changes in β-cell mass, phenotype, and function. Stage 1 is …
Five-year follow-up after clinical islet transplantation
Islet transplantation can restore endogenous β-cell function to subjects with type 1 diabetes.
Sixty-five patients received an islet transplant in Edmonton as of 1 November 2004. Their …
Sixty-five patients received an islet transplant in Edmonton as of 1 November 2004. Their …
Defining outcomes for β‐cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA/EPITA opinion leaders workshop
MR Rickels, PG Stock, EJP De Koning… - Transplant …, 2018 - Wiley Online Library
Summary β‐cell replacement therapy, available currently as pancreas or islet
transplantation, has developed without a clear definition of graft functional and clinical …
transplantation, has developed without a clear definition of graft functional and clinical …
Autoimmune polyendocrine syndromes
GS Eisenbarth, PA Gottlieb - New England Journal of Medicine, 2004 - Mass Medical Soc
This review considers the pathogenesis, scope, and treatment of autoimmune polyendocrine
syndromes. Although some of the component disorders such as thyroid autoimmunity and …
syndromes. Although some of the component disorders such as thyroid autoimmunity and …
The human islet: mini-organ with mega-impact
JT Walker, DC Saunders, M Brissova… - Endocrine …, 2021 - academic.oup.com
This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …
development, function, and dysfunction. After providing a historical timeline of key …