Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug
administration routes. Oral and injectable drug administration are the most common routes …

Implantable drug delivery systems advocate a wide array of potential benefits, including
effective administration of drugs at lower concentrations and fewer side-effects whilst …

Ultra-long-acting integrase strand transfer inhibitors were created by screening a library of
monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led to an 18 …

Introduction Poor or inconsistent adherence to daily oral pre-exposure prophylaxis (PrEP)
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …

The aim of this study was to better understand the impact of the chemistry of poly (lactic-co-
glycolic acid)(PLGA) polymers on the resulting drug release kinetics from implants prepared …

Biodegradable polymers have emerged as fascinating materials due to their non-toxicity,
environmentally benign nature and good mechanical strength. The toxic effects of non …

Objectives Poly (glycerol sebacate) urethane (PGSU) elastomers formulated with 4′-
ethynyl-2-fluoro-2′-deoxyadenosine (EFdA), levonorgestrel (LNG), or a combination …

Dolutegravir (DTG) is an antiretroviral drug approved in the year 2013, and being
categorized as a BCS-II molecule, it possesses solubility issues. In order to enhance the …

In situ forming implants (ISFI) based on poly (lactic-co-glycolic acid)(PLGA) are promising
long-acting injectable depots for the treatment of human immunodeficiency virus-1 infection …

Additive manufacturing has long been acclaimed as the tool for next-generation drug
delivery device production. An ongoing challenge has remained with the best method of …