Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

Classical itch studies have focused on immunoglobulin E (IgE)-mediated mast cell activation
and histamine release. Recently, members of the Mas-related G-protein-coupled receptor …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

Fibromyalgia Syndrome (FMS) is a disorder of chronic, generalized muscular pain,
accompanied by sleep disturbances, fatigue and cognitive dysfunction. There is no definitive …

Allergic contact dermatitis is a common skin disease associated with inflammation and
persistent pruritus. Transient receptor potential (TRP) ion channels in skin-innervating …

Recent findings have shed new light on the role of peripheral nerves in the skin and
established a modern concept of cutaneous neurobiology. Closely related monodirectional …

The capacity of fibroblasts to produce and organize the extracellular matrix and to
communicate with other cells makes them a central component of tissue biology. Even so …

Mast cells are immune cells critical in the pathogenesis of allergic, but also inflammatory and
autoimmune diseases through release of many pro-inflammatory cytokines such as IL-8 and …

Neprilysin has a major role in both the generation and degradation of bioactive peptides.
LCZ696 (valsartan/sacubitril, Entresto), the first of the new ARNI (dual-acting angiotensin …