[HTML][HTML] Myasthenia gravis: epidemiology, pathophysiology and clinical manifestations

L Dresser, R Wlodarski, K Rezania… - Journal of clinical medicine, 2021 - mdpi.com
Myasthenia gravis (MG) is an autoimmune neurological disorder characterized by defective
transmission at the neuromuscular junction. The incidence of the disease is 4.1 to 30 cases …

Myasthenia gravis: subgroup classification and therapeutic strategies

NE Gilhus, JJ Verschuuren - The Lancet Neurology, 2015 - thelancet.com
Myasthenia gravis is an autoimmune disease that is characterised by muscle weakness and
fatigue, is B-cell mediated, and is associated with antibodies directed against the …

[HTML][HTML] The neuromuscular junction in health and disease: molecular mechanisms governing synaptic formation and homeostasis

PM Rodríguez Cruz, J Cossins, D Beeson… - Frontiers in molecular …, 2020 - frontiersin.org
The neuromuscular junction (NMJ) is a highly specialized synapse between a motor neuron
nerve terminal and its muscle fiber that are responsible for converting electrical impulses …

[HTML][HTML] Autoantibody specificities in myasthenia gravis; implications for improved diagnostics and therapeutics

K Lazaridis, SJ Tzartos - Frontiers in immunology, 2020 - frontiersin.org
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and
fatiguability of skeletal muscles. It is an antibody-mediated disease, caused by …

Myasthenia gravis—autoantibody characteristics and their implications for therapy

NE Gilhus, GO Skeie, F Romi, K Lazaridis… - Nature reviews …, 2016 - nature.com
Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies that target the
neuromuscular junction, leading to muscle weakness and fatigability. Currently available …

Neuromuscular junction formation, aging, and disorders

L Li, WC Xiong, L Mei - Annual review of physiology, 2018 - annualreviews.org
Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory,
perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed …

[HTML][HTML] Mechanisms regulating neuromuscular junction development and function and causes of muscle wasting

LA Tintignac, HR Brenner… - Physiological …, 2015 - journals.physiology.org
The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …

[HTML][HTML] Drugs that induce or cause deterioration of myasthenia gravis: an update

S Sheikh, U Alvi, B Soliven, K Rezania - Journal of Clinical Medicine, 2021 - mdpi.com
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder which is characterized
by presence of antibodies against acetylcholine receptors (AChRs) or other proteins of the …

[HTML][HTML] Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society

N Melzer, T Ruck, P Fuhr, R Gold, R Hohlfeld… - Journal of …, 2016 - Springer
Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular
synaptic transmission. The clinical hallmark of MG consists of fluctuating fatigability and …

Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders

MG Huijbers, A Marx, JJ Plomp, R Le Panse… - The Lancet …, 2022 - thelancet.com
Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction
disorders. Although a plethora of immunosuppressive treatments exist, no cure is available …