Two are better than one: Quantum mechanics/molecular mechanics (QM/MM) methods are
the state‐of‐the‐art computational technique for treating reactive and other “electronic” …

Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …

The scope of this article is to present an overview of the Density Functional based Tight
Binding (DFTB) method and its applications. The paper introduces the basics of DFTB and …

Histone lysine and arginine residues are subject to a wide array of post-translational
modifications including methylation, citrullination, acetylation, ubiquitination, and …

Sphingolipids have emerged as bioeffector molecules, controlling various aspects of cell
growth and proliferation in cancer, which is becoming the deadliest disease in the world …

In this study, the inhibitor 2 of protein phosphatase 2A (I2PP2A) was identified in vitro and in
situ as a ceramide-binding protein, which exhibits stereoisomer specificity and fatty acid …

We applied peptide array methylation to determine an optimized target sequence for the
SET7/9 (KMT7) protein lysine methyltransferase. Based on this, we identified 91 new …

Protein methyltransferases have been shown to methylate histone and non-histone proteins,
leading to regulation of several biological processes that control cell homeostasis. Over the …

Purpose.: Diabetes induces oxidative imbalance in the retina and impairs Nrf2-mediated
antioxidant response, and elevates Keap1, the cytoplasmic repressor of Nrf2. The goal of …

Both genetic and epigenetic alterations are responsible for the stepwise initiation and
progression of cancers. Only epigenetic aberrations can be reversible, allowing the …