Luteolin, a potent anticancer compound: from chemistry to cellular interactions and synergetic perspectives

H Singh Tuli, P Rath, A Chauhan, K Sak, D Aggarwal… - Cancers, 2022 - mdpi.com
Simple Summary Common flavonoid luteolin 3′, 4′, 5, 7-tetrahydroxyflavone has
immense potential to be utilized as a chemopreventive dietary molecule. According to …

Molecular targets of luteolin in cancer

MJ Tuorkey - European Journal of Cancer Prevention, 2016 - journals.lww.com
Many food-derived phytochemical compounds and their derivatives represent a cornucopia
of new anticancer compounds. Despite extensive study of luteolin, the literature has no …

Multi-faceted role of luteolin in cancer metastasis: EMT, angiogenesis, ECM degradation and apoptosis

MT Rocchetti, F Bellanti, M Zadorozhna… - International Journal of …, 2023 - mdpi.com
Luteolin (3′, 4′, 5, 7-tetrahydroxyflavone), a member of the flavonoid family derived from
plants and fruits, shows a wide range of biomedical applications. In fact, due to its anti …

Natural polyphenols for treatment of colorectal cancer

Y Zhang, K Liu, C Yan, Y Yin, S He, L Qiu, G Li - Molecules, 2022 - mdpi.com
Colorectal cancer (CRC) is a prevalent and serious gastrointestinal malignancy with high
mortality and morbidity. Chemoprevention refers to a newly emerged strategy that uses …

Phenolic phytochemicals for prevention and treatment of colorectal cancer: A critical evaluation of in vivo studies

S De, S Paul, A Manna, C Majumder, K Pal, N Casarcia… - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is a significant cause of death worldwide. The
inefficacy of the current treatment regimens is reflected in the frequent recurrence and …

Myricetin suppresses breast cancer metastasis through down‐regulating the activity of matrix metalloproteinase (MMP)‐2/9

Y Ci, Y Zhang, Y Liu, S Lu, J Cao, H Li… - Phytotherapy …, 2018 - Wiley Online Library
Tumour metastasis is the major cause of breast cancer mortality. Myricetin, a natural
polyphenol, is found in teas, wines, and berries. The pharmacodynamic action and …

Luteolin alleviates polycystic ovary syndrome in rats by resolving insulin resistance and oxidative stress

Y Huang, X Zhang - American Journal of Physiology …, 2021 - journals.physiology.org
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by elevated
secretion of androgen, commonly associated with insulin resistance (IR), which could …

Luteolin-fabricated ZnO nanostructures showed PLK-1 mediated anti-breast cancer activity

SP Kollur, SK Prasad, S Pradeep, R Veerapur, SS Patil… - Biomolecules, 2021 - mdpi.com
The present work describes a facile and convenient procedure for synthesizing zinc oxide
nanoparticles using luteolin isolated from Eclipta alba plant (L-ZnONPs) at room …

Natural inhibitors of PI3K/AKT signaling in breast cancer: emphasis on newly-discovered molecular mechanisms of action

Y Safdari, M Khalili, MA Ebrahimzadeh… - Pharmacological …, 2015 - Elsevier
Epidermal growth factor receptor (EGFR) plays a critical role in the initiation and progression
of a variety of human cancers, including breast cancer. An important signaling pathway …

Luteolin ameliorates dextran sulfate sodium-induced colitis in mice possibly through activation of the Nrf2 signaling pathway

Y Li, L Shen, H Luo - International Immunopharmacology, 2016 - Elsevier
Background Luteolin has a reputation for being a safe and effective natural antioxidant that
has strong radical scavenging and cell protective properties. The role of oxidative stress in …