Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

The development of atomic force microscopy (AFM) has opened up a wide range of novel
opportunities in nanoscience and new modalities of observation in complex biological …

Studies of proteins' formation of amyloid fibrils have revealed that potentially cytotoxic
oligomers frequently accumulate during fibril formation. An important question in the context …

There is great interest in developing reproducible high-throughput screens to identify small
molecular inhibitors of protein fibrillization and aggregation for possible therapy against …

Because of the insolubility and polymeric properties of amyloid fibrils, techniques used
conventionally to analyze protein structure and dynamics have often been hampered …

An increasing number of neurodegenerative diseases are being found to be associated with
the abnormal accumulation of aggregated proteins in the brain. In Parkinson's disease, this …

Although previous studies have demonstrated the involvement of nitrated α-synuclein in
neurodegenerative disorders (synucleinopathies), the effects of nitrated α-synuclein and the …

Associated with neurodegenerative disorders such as Alzheimer, Parkinson, or prion
diseases, the conversion of soluble proteins into amyloid fibrils remains poorly understood …

Abstract α-Synuclein is a protein that aggregates as amyloid fibrils in the brains of patients
with Parkinson's disease and dementia with Lewy bodies. Small oligomers of α-synuclein …

Many neurodegenerative diseases are linked with formation of amyloid aggregates. It is
increasingly accepted that not the fibrils but rather oligomeric species are responsible for …